Question · asked by 0 reviews
Antibiotics vs placebo: Serious adverse events
- Population
- Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi 2010) recruited patients who required systemic steroids or antibiotics for exacerbations or patients on supplemental oxygen
- Intervention
- Antibiotics
- Comparison
- placebo
- Outcome
- Serious adverse events
Antibiotics showed no clear difference in serious adverse events compared with placebo (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antibiotics vs placebo Serious adverse events · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies… Antibiotics showed no clear difference in serious adverse events compared with placebo (moderate certainty). Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) (2013) · Cochrane Headline outcomes onlyearlier version CD009764.PUB2, superseded | OR 0.88 [0.73, 1.07] | 4 studies · 2411 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.