Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo: Patient Global Impression of Change much or very much improved
Serotonin noradrenaline reuptake inhibitors may leads to higher patient Global Impression to be much or very much improved (PGIC) compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Serotonin noradrenaline reuptake inhibitors vs placebo Patient Global Impression to be much or very much improved (PGIC) · people with fibromyalgia Serotonin noradrenaline reuptake inhibitors may leads to higher patient Global Impression to be much or very much improved (PGIC) compared with placebo (low certainty). Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia (2018) · Cochrane Headline outcomes only | RD 0.19 [0.12, 0.26] | 6 studies · 2918 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia 2018 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.