5‐ASA vs purine antimetabolites: Serious adverse events
- Population
- people with surgically‐induced remission in Crohn's disease
- Intervention
- 5‐ASA
- Comparison
- purine antimetabolites
- Outcome
- Serious adverse events
It is very uncertain whether 5‐ASA changes serious adverse events compared with purine antimetabolites (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
5‐ASA vs purine antimetabolites Serious adverse events · people with surgically‐induced remission in Crohn's disease It is very uncertain whether 5‐ASA changes serious adverse events compared with purine antimetabolites (very low certainty). Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease (2019) · Cochrane Headline outcomes only | RR 0.3 [0.11, 0.8] | 3 studies · 311 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- 5‐ASA vs anti TNF‐ɑ · people with surgically‐induced remission in Crohn's disease · 1 review
- 5‐ASA vs no treatment · people with surgically‐induced remission in Crohn's disease · 1 review
- 5‐ASA vs placebo · people with surgically‐induced remission in Crohn's disease · 1 review
- 5‐ASA vs placebo · patients with maintenance of medically‐induced remission in Crohn's disease · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.