Question · asked by 1 review
Zinc vs placebo: Frequency of crisis
- Population
- people with sickle cell disease
- Intervention
- Zinc
- Comparison
- placebo
- Outcome
- Frequency of crisis
Zinc showed no clear difference in frequency of crisis compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Zinc vs placebo Frequency of crisis · children and adults with sickle cell disease Zinc showed no clear difference in frequency of crisis compared with placebo (low certainty). Antioxidant supplementation for sickle cell disease (2024) · Cochrane Headline outcomes only | Rate ratio 0.62 [0.17, 2.29] | 1 study · 36 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.