Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol: Patients not using rescue medication at 6 hours
- Population
- Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe pain; adults approximately 15 to 65 years, both sexes
- Intervention
- Ibuprofen (single postoperative oral dose; 200 mg to 512 mg)
- Comparison
- paracetamol
- Outcome
- Patients not using rescue medication at 6 hours
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher patients not using rescue medication at 6 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs Paracetamol (acetaminophen) (single postoperative oral dose; 600 mg to 1000 mg) Patients not using rescue medication at 6 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline… · 6 hours postdosing, Ibuprofen 400 mg vs paracetamol 1000 mg Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher patients not using rescue medication at 6 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty). Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth (2013) · Cochrane All outcomes | RR 1.50 [1.25, 1.79] | 4 studies · 542 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes | 2013-05 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.