Monoclonal antibodies vs placebo: Anti‐endotoxin ‐ HA‐1A versus placebo, all‐cause mortality
It is very uncertain whether monoclonal antibodies changes anti‐endotoxin ‐ HA‐1A versus placebo, all‐cause mortality compared with placebo (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Monoclonal antibodies vs placebo Anti‐endotoxin ‐ HA‐1A versus placebo, all‐cause mortality · patients with sepsis, severe sepsis, septic shock It is very uncertain whether monoclonal antibodies changes anti‐endotoxin ‐ HA‐1A versus placebo, all‐cause mortality compared with placebo (very low certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.8 [0.54, 1.2] | 3 studies · 2668 participants | Very low |
Monoclonal antibodies vs placebo Sensitivity analysis by quality, anti‐endotoxin, all‐cause mortality · patients with sepsis, severe sepsis, septic shock Monoclonal antibodies showed no clear difference in sensitivity analysis by quality, anti‐endotoxin, all‐cause mortality compared with placebo (moderate certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 1.01 [0.94, 1.09] | 6 studies · 4443 participants | Moderate |
Monoclonal antibodies vs placebo Anti‐endotoxins versus placebo, all‐cause mortality · patients with sepsis, severe sepsis, septic shock Monoclonal antibodies showed no clear difference in anti‐endotoxins versus placebo, all‐cause mortality compared with placebo (low certainty). Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013) · Cochrane Headline outcomes only | RR 0.92 [0.79, 1.06] | 8 studies · 4676 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.