Question · asked by 1 review
Clarithromycin + SRP vs SRP: Adverse events
- Population
- Adults with periodontitis (chronic and aggressive)
- Intervention
- Clarithromycin + SRP
- Comparison
- SRP
- Outcome
- Adverse events
Clarithromycin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Clarithromycin + SRP vs SRP Adverse events · Adults with periodontitis (chronic and aggressive) Clarithromycin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported. Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | Both included trials reported adverse events in the clarithromycin + SRP group: unpalatable taste and mild gastric intolerance in 2 patients (Pradeep 2011); mild gastrointestinal discomfort in 2 patients (Rebelatto… | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes | 2020-03 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.