Loratadine 10 mg vs placebo (4‐week intervention): Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period
- Population
- adults with eczema
- Intervention
- Loratadine 10 mg
- Comparison
- placebo (4‐week intervention)
- Outcome
- Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period
Loratadine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Loratadine 10 mg/d vs placebo (4‐week intervention) Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · male and female adults aged 15 years and older with eczema Loratadine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty). Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema (2019) · Cochrane Headline outcomes only | RR 0.25 [0.01, 5.76] | 1 study · 28 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Loratadine 10 mg vs placebo (2‐week intervention) · adults with eczema · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.