Brexpiprazole vs antidepressive agents: Change in depressive symptoms
Brexpiprazole showed no clear difference in change in depressive symptoms at 8 weeks compared with antidepressive agents (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Brexpiprazole vs antidepressive agents Change in depressive symptoms at 8 weeks · participants of any age with a primary diagnosis of major depressive disorder Brexpiprazole showed no clear difference in change in depressive symptoms at 8 weeks compared with antidepressive agents (high certainty). Brexpiprazole versus placebo or other antidepressive agents for treating depression (2023) · Cochrane Headline outcomes only | MD 1.39 | 8 studies · 3263 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Brexpiprazole versus placebo or other antidepressive agents for treating depression 2023 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.