Question · asked by 1 review

Anti‐leukotrienes & ICS vs ICS dose increase: Number of participants experiencing one or more episode requiring treatment with oral steroids

Anti‐leukotrienes & ICS may leads to lower participants with one or more exacerbations requiring oral… compared with higher dose ICS (low certainty).

What each review found

Current versions only
FindingEffectStudiesGRADE certainty
Anti‐leukotrienes & ICS vs higher dose ICS
Participants with one or more exacerbations requiring oral corticosteroids · Children with asthma
Anti‐leukotrienes & ICS may leads to lower participants with one or more exacerbations requiring oral… compared with higher dose ICS (low certainty).
Addition of anti‐leukotriene agents to inhaled corticosteroids in children with persistent asthma (2013) · Cochrane Headline outcomes only
Risk Ratio 0.821 study · 182 participantsLow

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Addition of anti‐leukotriene agents to inhaled corticosteroids in children with persistent asthma
2013 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.