Same question across reviews · CL0332
prognostic :: Exposure: genetic -> Other outcome
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
1
Questions
3
current versions
GRADE rated
0
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots) Noticeable impact of gene sequencing on diagnosing/managing oral conditions · Human patients (any age) with oral-cavity related disorders (e.g. dental caries, periodontitis, gingivitis,… · Overall Gene sequencing applications to combat oral-cavity related disorders: a systematic review with meta-analysis. (2024) | RR 0.50 [0.46, 0.54] | 8 studies · 2211 participants | Ungraded |
Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots) Noticeable impact of gene sequencing on diagnosing/managing oral conditions · Human patients (any age) with oral-cavity related disorders (e.g. dental caries, periodontitis, gingivitis,… · Overall Gene sequencing applications to combat oral-cavity related disorders: a systematic review with meta-analysis. (2024) | OR 0.30 [0.26, 0.33] | 8 studies · 2211 participants | Ungraded |
Gene sequencing (GS) applied to diagnose/manage oral conditions (predominantly 16S rRNA next-generation sequencing of the oral microbiome; also genome-wide/whole-genome sequencing) vs Negligible ('abysmal') effect of gene sequencing; no separate comparator arm (within-sample event contrast in the forest plots) Reduction in occurrence of oral conditions · Human patients (any age) with oral-cavity related disorders (e.g. dental caries, periodontitis, gingivitis,… · Overall Gene sequencing applications to combat oral-cavity related disorders: a systematic review with meta-analysis. (2024) | RD -0.29 [-0.32, -0.26] | 8 studies · 2211 participants | Ungraded |