Same question across reviews · CL0290
intervention :: Unclassified intervention -> Periodontal/gingival
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
28
Questions
142
current versions
GRADE rated
40
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs No active intervention/usual care Gingival index (GI) · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age · 3-4 months Treatment of periodontitis for glycaemic control in people with diabetes mellitus (2022) · Cochrane | SMD -1.75 [-2.27, -1.24] | 12 studies | Ungraded |
Traditional screening (referral card given if the inspecting dentist judges the child needs to see a dentist) vs No screening Gingivitis measured by any validated index · School children (aged 4 to 15 years), primary and secondary schools in the UK and India School dental screening programmes for oral health (2022) · Cochrane | No studies measured gingivitis (by any validated index). | 0 studies | No studies |
Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs No active intervention/usual care Bleeding on probing (BOP) · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age · 3-4 months Treatment of periodontitis for glycaemic control in people with diabetes mellitus (2022) · Cochrane | MD -15.56 [-21.77, -9.36] | 14 studies | Ungraded |
Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances Gingival index (GI) · Adolescents/teenagers undergoing orthodontic treatment · 18 months, Adolescents Impact of Aligners and Fixed Appliances on Oral Health during Orthodontic Treatment: A Systematic Review and… (2021) | MD -0.57 [-0.93, -0.21] | 1 study | Ungraded |
Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances Gingival index (GI) · Adults undergoing orthodontic treatment · 6 to 12 weeks, Adults Impact of Aligners and Fixed Appliances on Oral Health during Orthodontic Treatment: A Systematic Review and… (2021) | MD -0.10 [-0.35, 0.15] | 1 study | Ungraded |
Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances Bleeding on probing (BOP) · Adults undergoing orthodontic treatment · 6 to 12 weeks, Adults Impact of Aligners and Fixed Appliances on Oral Health during Orthodontic Treatment: A Systematic Review and… (2021) | MD -0.26 [-0.77, 0.26] | 2 studies · 62 participants | Very low |
Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances Simplified gingival index (s-GI) · Adolescents/teenagers undergoing orthodontic treatment · 1 month, Adolescents Impact of Aligners and Fixed Appliances on Oral Health during Orthodontic Treatment: A Systematic Review and… (2021) | MD -8.46 [-10.47, -6.45] | 1 study | Ungraded |
Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling Bleeding on probing (BOP) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension · Long term, People diagnosed with periodontitis Effect of periodontal treatments on blood pressure (2021) · Cochrane | MD -0.40 [-0.45, -0.35] | 1 study | Ungraded |
Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances Full-mouth bleeding score (FMBS) · Adolescents/teenagers undergoing orthodontic treatment · 12 months, Adolescents Impact of Aligners and Fixed Appliances on Oral Health during Orthodontic Treatment: A Systematic Review and… (2021) | MD -20.44 [-22.98, -17.90] | 1 study | Ungraded |
Periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment) Bleeding on probing (BOP) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension · Long term, People diagnosed with periodontitis and other cardiovascular diseases except hypertension Effect of periodontal treatments on blood pressure (2021) · Cochrane | MD -36.80 [-46.47, -27.13] | 1 study · 48 participants | Ungraded |
Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling Bleeding on probing (BOP) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension · Short term, People diagnosed with periodontitis Effect of periodontal treatments on blood pressure (2021) · Cochrane | MD -0.42 [-0.47, -0.37] | 1 study | Ungraded |
Self-ligating brackets vs Conventional brackets Harms (discomfort, periodontal/gingival health, root resorption) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · up to 9 months Orthodontic treatment for crowded teeth in children (2021) · Cochrane | No evidence of differences between self-ligating and conventional brackets for discomfort (Atik 2014, Miles 2010), plaque/gingival index and probing depth (Atik 2014), or maxillary incisor root resorption (Aras 2018).… | 3 studies | Ungraded |
Azithromycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -3.32 [-6.23, -0.42] | 6 studies · 228 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.00 [-0.09, 0.09] | 1 study · 21 participants | Very low |
Doxycycline + SRP vs Metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.05 [-0.22, 0.12] | 1 study · 22 participants | Ungraded |
Metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -6.90 [-22.10, 8.30] | 1 study · 22 participants | Very low |
Clinical examination with risk-based recall vs Clinical examination with 24-month recall Periodontal disease: gingival bleeding (percentage of sites) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.07 [-4.10, 3.96] | 1 study · 279 participants | High |
Amoxicillin + metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -2.05 [-2.98, -1.11] | 13 studies · 460 participants | Ungraded |
Clindamycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Surgical removal (extraction) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth Undesirable outcomes associated with removal (alveolar osteitis/postoperative infection, nerve injury, damage to adjacent teeth, bleeding, osteonecrosis, inflammation/infection) · Adolescents or adults with asymptomatic disease-free impacted wisdom teeth Surgical removal versus retention for the management of asymptomatic disease‐free impacted wisdom teeth (2020) · Cochrane | Undesirable outcomes associated with removal: Not measured. No included studies measured outcomes or adverse events associated with removal (alveolar osteitis/postoperative infection, nerve injury, damage to adjacent… | 0 studies | No studies |
Levofloxacin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.38 [-3.30, 0.54] | 2 studies · 131 participants | Ungraded |
Clarithromycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -4.70 [-8.42, -0.98] | 1 study · 40 participants | Ungraded |
Clinical examination with risk-based recall vs Clinical examination with 6-month recall Periodontal disease: gingival bleeding (percentage of sites) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD 0.78 [-1.17, 2.73] | 1 study · 1472 participants | High |
Azithromycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.28 [-4.32, 1.76] | 2 studies · 110 participants | Very low |
Clinical examination with 24-month recall vs Clinical examination with 12-month recall Periodontal disease · Regular-attending primary-care dental patients aged 3, 16 or 18 years at entry (aged up to 20; low caries risk) · 2 years Recall intervals for oral health in primary care patients (2020) · Cochrane | Summary of findings 1 lists 'Periodontal disease: Not reported' for the 24-month versus 12-month comparison (Wang 1992 did not measure it). | 0 studies | No studies |
Doxycycline + SRP vs Metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clinical examination with 24-month recall vs Clinical examination with 6-month recall Periodontal disease: gingival bleeding (percentage of sites) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.91 [-5.02, 3.20] | 1 study · 271 participants | Moderate |
Amoxicillin + metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -5.32 [-12.02, 1.37] | 5 studies · 172 participants | Ungraded |
Clinical examination with 24-month recall vs Clinical examination with 6-month recall Periodontal disease: probing pocket depth (mm) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD -0.03 [-0.12, 0.06] | 1 study · 270 participants | Moderate |
Cefixime + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.48 [-0.60, -0.37] | 1 study · 60 participants | Ungraded |
Doxycycline + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.01 [-0.21, 0.19] | 1 study · 21 participants | Ungraded |
Clinical examination with risk-based recall vs Clinical examination with 24-month recall Periodontal disease: probing pocket depth (mm) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD 0.10 [0.01, 0.19] | 1 study · 279 participants | Moderate |
Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 4.00 [-1.09, 9.09] | 1 study · 46 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs Tetracycline + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.60 [-14.03, 10.83] | 1 study · 8 participants | Ungraded |
Clinical examination with risk-based recall vs Clinical examination with 6-month recall Periodontal disease: probing pocket depth (mm) · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders) · 4 years Recall intervals for oral health in primary care patients (2020) · Cochrane | MD 0.03 [-0.01, 0.07] | 1 study · 1463 participants | High |
Metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -9.00 [-16.59, -1.40] | 4 studies · 108 participants | Ungraded |
Doxycycline + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Metronidazole + SRP vs Amoxicillin + metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 4.46 [-23.48, 32.40] | 3 studies · 84 participants | Ungraded |
Doxycycline + SRP vs Metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.07 [-0.29, 0.15] | 1 study · 22 participants | Ungraded |
Moxifloxacin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -3.40 [-3.72, -3.08] | 1 study · 40 participants | Ungraded |
Metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -4.62 [-18.83, 9.58] | 2 studies · 45 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.10 [-0.19, -0.01] | 1 study · 21 participants | Ungraded |
Azithromycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -3.18 [-7.01, 0.65] | 6 studies · 216 participants | Ungraded |
Levofloxacin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.93 [-2.88, 1.02] | 2 studies · 131 participants | Ungraded |
Clindamycin + SRP vs Doxycycline + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Metronidazole + SRP vs Amoxicillin + metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 20.85 [3.31, 38.39] | 1 study · 22 participants | Ungraded |
Doxycycline + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.09 [-0.29, 0.11] | 1 study · 21 participants | Ungraded |
Amoxicillin + metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -8.06 [-14.26, -1.85] | 2 studies · 389 participants | Very low |
Tetracycline + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Moxifloxacin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.80 [-1.12, -0.48] | 1 study · 40 participants | Ungraded |