Same question across reviews · CL0181
intervention :: Herbal/natural product -> Adverse effects/fluorosis
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
5
Questions
10
current versions
GRADE rated
0
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Cell death / cytotoxicity · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | GSE showed a very low level of cell damage (<1%, few visible dead cells) (Furiga). | 1 study | Ungraded |
Grape seed extract or grape seed flavonoid fractions vs No extract or vehicle control; other antimicrobial agents Cell damage or cytotoxicity · Streptococcus mutans cultures and biofilms Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | no estimate extracted | 1 study | Ungraded |
Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride) Cell death / cytotoxicity induction · Streptococcus mutans (in vitro cultures and biofilms) Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024) | Cranberry extract produced a time- and concentration-dependent reduction in bacterial count, with a 50% reduction after 10 h (Singhal). | 1 study | Ungraded |
Primary closure of the extraction socket with a mucoperiosteal flap vs Application of platelet-rich fibrin (PRF) without primary closure Rate of complications and side effects of the intervention · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ) · 90 days Interventions for managing medication‐related osteonecrosis of the jaw (2022) · Cochrane | No intraoperative complications occurred in either group. Postoperative complications: 6 participants (15.4%) in the mucoperiosteal flap group and 1 participant (2.6%) in the PRF group. | 1 study · 77 participants | Ungraded |
Lingual nerve retractor (subperiosteal or Free's) vs No retractor Adverse effects (reactionary bleeding) · Adults with mandibular third molars requiring removal · up to 30 days Surgical techniques for the removal of mandibular wisdom teeth (2020) · Cochrane | no estimate extracted | NR | No studies |
Herbal extracts (tea components; Chinese herbal mixture; freeze-dried black raspberry gel) vs Placebo or no treatment Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia · up to 3 months Interventions for treating oral leukoplakia to prevent oral cancer (2016) · Cochrane | SoF 4, Safety of the intervention up to 3 months: '3 studies measured adverse effects: green tea extract capsules caused high frequency (93%) of adverse effects of varying severity in 1 study; the mixed tea study did… | 3 studies | Ungraded |
LongoVital (herbal plus vitamin supplement) vs Placebo Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 4 months Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | Reported adverse events were minor and evenly distributed between the groups. | 1 study · 40 participants | Ungraded |
Bee propolis (one 500 mg capsule per day) vs Placebo Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 6 months (minimum) Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | Propolis was associated with low rates of minimal side effects. | 1 study · 19 participants | Ungraded |
LongoVital (herbal plus vitamin component) vs LongoVital (herbal component alone) Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 4 months Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | Reported adverse events were minor and evenly distributed between the groups (Kolseth 2005). | 1 study · 40 participants | Ungraded |
LongoVital (herbal component alone) vs Placebo Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | Reported adverse events were minor and evenly distributed between the groups (Kolseth 2005). 'Very few and mostly harmless side-effects' were observed (Bratel 2005). | 2 studies | Ungraded |