Same question across reviews · CL0124
intervention :: Exposure/condition: systemic-oral -> Periodontal/gingival
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
1
Questions
5
current versions
GRADE rated
5
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 1.29 [0.58, 2.88] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Acute necrotising ulcerative gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.00 [0.00, 0.02] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Periodontal disease prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.82 [0.46, 1.44] | 2 studies · 250 participants | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in linear gingival erythema between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 1 study(ies). | 1 study | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in gingivitis between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 2 study(ies). | 2 studies | Very low |