Same question across reviews · CL0118
intervention :: Exposure: microbial -> Other outcome
ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.
Reviews
1
Questions
3
current versions
GRADE rated
1
Review overlap (CCA)
NR
over all included studies of these reviews, not this question only
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Botulinum toxin (BoNT) injection into salivary glands vs Placebo injection Drooling Severity and Frequency Scale (DSFS) score · Adults with Parkinson's disease and sialorrhea (drooling) · Approximately 1 month post-injection (one study ~1 week), BoNT type A The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's… (2023) | SMD -0.80 [-1.25, -0.36] | 4 studies · 88 participants | Ungraded |
Botulinum toxin (BoNT) injection into salivary glands vs Placebo injection Drooling Severity and Frequency Scale (DSFS) score · Adults with Parkinson's disease and sialorrhea (drooling) · Approximately 1 month post-injection (one study ~1 week), BoNT type B The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's… (2023) | SMD -1.11 [-1.48, -0.74] | 5 studies · 136 participants | Ungraded |
Botulinum toxin (BoNT) injection into salivary glands vs Placebo injection Drooling Severity and Frequency Scale (DSFS) score · Adults with Parkinson's disease and sialorrhea (drooling) · Approximately 1 month post-injection (one study ~1 week) The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's… (2023) | SMD -0.98 [-1.27, -0.70] | 9 studies · 224 participants | High |