Same question across reviews · CL0019

aetiology :: Exposure: microbial -> Microbiological/plaque

ProposalThis cluster groups questions by review type, intervention category and outcome domain. It is a proposal pending human validation, so questions in it may differ in population, comparator or timing.

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Questions

current versions

GRADE rated

Review overlap (CCA)

0.000

over all included studies of these reviews, not this question only

Question	Effect	Evidence	Status / GRADE
Salivary Actinobacillus level vs Not specified Salivary S. mutans level · Patients with aggressive periodontitis · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)	OR 0.08 [0.01, 0.85]	1 study	Ungraded
Salivary Actinobacillus level (high) vs Not specified Salivary S. mutans level · Humans with salivary bacteria measured · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)	OR 2.39 [1.00, 5.71]	1 study	Ungraded
Salivary F. nucleatum level vs Not specified Salivary S. mutans level · Humans with salivary bacteria measured · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)	OR 6.03 [1.55, 23.45]	1 study	Ungraded
Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome Differential microbial abundance / taxa predictive of caries · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies… Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. (2022)	Mean-decrease-accuracy discriminating taxa: Capnocytophaga HMT-338, Lactobacillus panis, Treponema HMT-230, Bifidobacterium longum, Delftia acidovorans, Staphylococcus schleiferi; higher log2FC in caries: Selenomonas HMT-146, Aggregatibacter actinomycetemcomitans, Actinomyces HMT-896, Treponema HMT-257; Streptococcus not predictive	19 studies · 2016 participants	Ungraded

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