Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by The Efficacy of Mesenchymal Stem Cell-Based Therapy for Sjögren's Syndrome: A Systematic Review and Meta-Analysis of Preclinical Studies.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| miRNA let-7f-5p-encapsulated labial gland MSC-derived EVs ameliorate experimental Sjögren’s syndrome by suppressing Th17 cells via targeting… Xie 2025 · Xie Yufei, Chai Maosheng, et al. · Journal of Nanobiotechnology DOI:10.1186/s12951-025-03308-y | 2025 | 1 | none stated | not extracted yet |
| <scp>SHED</scp> ‐exos promote saliva secretion by suppressing <scp> <i>p‐</i> ERK1 </scp> /2‐mediated apoptosis in glandular cells Chu 2024 · Chu Wei‐Xia, Ding Chong, et al. · Oral Diseases DOI:10.1111/odi.14776 | 2023 | 1 | none stated | not extracted yet |
| Dental pulp stem cell-derived exosomes revitalize salivary gland epithelial cell function in NOD mice via the GPER-mediated cAMP/PKA/CREB signaling… Hu 2023 · Hu Shilin, Chen Bo, et al. · Journal of Translational Medicine DOI:10.1186/s12967-023-04198-0 | 2023 | 1 | none stated | not extracted yet |
| Inhibitory Effects of Extracellular Vesicles from iPS-Cell-Derived Mesenchymal Stem Cells on the Onset of Sialadenitis in Sjögren's Syndrome Are… Zhao 2023 · Zhao Qingguo, Bae Eun-Hye, et al. · International journal of molecular sciences PMID:36982329 | 2023 | 1 | none stated | not extracted yet |
| Mesenchymal stem cell transplantation alleviates Sjögren's syndrome symptoms by modulating Tim-3 expression Sun 2022 · Sun Tian, Liu Shanshan, et al. · International Immunopharmacology DOI:10.1016/j.intimp.2022.109152 | 2022 | 1 | none stated | not extracted yet |
| Umbilical cord mesenchymal stem cells alleviate Sjögren’s syndrome and related pulmonary inflammation through regulating Vγ4+ IL-17+ T cells Cong 2022 · Cong Yan, Tang Xiaojun, et al. · Annals of Translational Medicine DOI:10.21037/atm-22-1855 | 2022 | 1 | none stated | not extracted yet |
| Labial Gland Mesenchymal Stem Cell Derived Exosomes-Mediated miRNA-125b Attenuates Experimental Sjogren's Syndrome by Targeting PRDM1 and… Xing 2022 · Xing Yixiao, Li Boya, et al. · Frontiers in immunology PMID:35444638 | 2022 | 1 | none stated | not extracted yet |
| Stem cells from exfoliated deciduous teeth transplantation ameliorates Sjögren's syndrome by secreting soluble PD-L1 Yang 2022 · Yang Ning, Liu Xuemei, et al. · Journal of Leukocyte Biology DOI:10.1002/jlb.6ma0921-752rr | 2021 | 1 | none stated | not extracted yet |
| Dental pulp-derived stem cell-conditioned media attenuates secondary Sjögren's syndrome via suppression of inflammatory cytokines in the… Ogata 2021 · Ogata Kenichi, Matsumura-Kawashima Mayu, et al. · Regenerative Therapy DOI:10.1016/j.reth.2021.01.006 | 2021 | 1 | none stated | not extracted yet |
| Secreted factors from dental pulp stem cells improve Sjögren’s syndrome via regulatory T cell-mediated immunosuppression Matsumura 2021 · Matsumura-Kawashima Mayu, Ogata Kenichi, et al. · Stem Cell Research & Therapy DOI:10.1186/s13287-021-02236-6 | 2021 | 1 | none stated | not extracted yet |
| Labial gland-derived mesenchymal stem cells and their exosomes ameliorate murine Sjögren's syndrome by modulating the balance of Treg and Th17 cells Li 2021 · Li Boya, Xing Yixiao, et al. · Stem Cell Research & Therapy DOI:10.1186/s13287-021-02541-0 | 2021 | 1 | none stated | not extracted yet |
| Identification of Molecules Responsible for Therapeutic Effects of Extracellular Vesicles Produced from iPSC-Derived MSCs on Sjo¨gren’s Syndrome Kim 2021 · Kim Hyemee, Zhao Qingguo, et al. · Aging and disease DOI:10.14336/ad.2021.0621 | 2021 | 1 | none stated | not extracted yet |
| Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren’s syndrome Hu 2020 · Hu Lei, Xu Junji, et al. · Cell Death & Disease DOI:10.1038/s41419-020-2359-6 | 2020 | 1 | none stated | not extracted yet |
| Human umbilical cord mesenchymal stem cells confer potent immunosuppressive effects in Sjögren’s syndrome by inducing regulatory T cells Liu 2021 · Liu Yanying, Li Chunlei, et al. · Modern Rheumatology DOI:10.1080/14397595.2019.1707996 | 2020 | 1 | none stated | not extracted yet |
| Mesenchymal stem cells inhibited the differentiation of MDSCs via COX2/PGE2 in experimental sialadenitis Qi 2020 · Qi Jingjing, Tang Xiaojun, et al. · Stem Cell Research & Therapy DOI:10.1186/s13287-020-01837-x | 2020 | 1 | none stated | not extracted yet |
| Mesenchymal Stem Cells Extract (MSCsE)-Based Therapy Alleviates Xerostomia and Keratoconjunctivitis Sicca in Sjogren's Syndrome-Like Disease. Abughanam 2019 · Abughanam Ghada, Elkashty Osama A, et al. · International journal of molecular sciences PMID:31557796 | 2019 | 1 | none stated | not extracted yet |
| Mesenchymal stem cell transplantation alleviates experimental Sjögren's syndrome through IFN-β/IL-27 signaling axis. Yao 2019 · Yao Genhong, Qi Jingjing, et al. · Theranostics PMID:31754394 | 2019 | 1 | none stated | not extracted yet |
| Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjögren’s Syndrome Hai 2018 · Hai Bo, Shigemoto-Kuroda Taeko, et al. · Stem Cells International DOI:10.1155/2018/2092315 | 2018 | 1 | none stated | not extracted yet |
| Mesenchymal stem cell transplantation ameliorates Sjögren’s syndrome via suppressing IL-12 production by dendritic cells Shi 2018 · Shi Bingyu, Qi Jingjing, et al. · Stem Cell Research & Therapy DOI:10.1186/s13287-018-1023-x | 2018 | 1 | none stated | not extracted yet |
| Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren’s Syndrome Aluri 2017 · Aluri Hema S., Samizadeh Mahta, et al. · Stem Cells International DOI:10.1155/2017/3134543 | 2017 | 1 | none stated | not extracted yet |
| Effect of mesenchymal stem cells on Sjögren-like mice and the microRNA expression profiles of splenic CD4+ T cells. Ruan 2017 · Ruan Guang-Feng, Zheng Ling, et al. · Experimental and therapeutic medicine PMID:28587347 | 2017 | 1 | none stated | not extracted yet |
| Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome Xu 2012 · Xu Junji, Wang Dandan, et al. · Blood DOI:10.1182/blood-2011-11-391144 | 2012 | 1 | none stated | not extracted yet |
| Mesenchymal Stromal Cells Improve Salivary Function and Reduce Lymphocytic Infiltrates in Mice with Sjögren's-Like Disease Khalili 2012 · Khalili Saeed, Liu Younan, et al. · PLoS ONE DOI:10.1371/journal.pone.0038615 | 2012 | 1 | none stated | not extracted yet |
| Bone marrow cells are a source of undifferentiated cells to prevent Sjögren's syndrome and to preserve salivary glands function in the non-obese… Khalili 2010 · Khalili Saeed, Liu Younan, et al. · The International Journal of Biochemistry & Cell Biology DOI:10.1016/j.biocel.2010.08.008 | 2010 | 1 | none stated | not extracted yet |
| Huang 2016 DOI:10.3760/cma.j.issn.2095-0160.2016.09.003 | NR | 1 | none stated | not extracted yet |