Primary study · included by 1 review

Efficacy of leukocyte-platelet-rich fibrin (L-PRF) and injectable platelet-rich fibrin (i-PRF) on the rate of canine retraction: a split mouth, randomized controlled trial.

Kamrani 2026 · Kamrani Aastha, Khera Amit Kumar, Raghav Pradeep, et al. · The Angle orthodontist · 2026

Included by

Outcome this study informsPooled effectEvidenceCertainty
Rate of canine retraction
L-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 2–3 months
MD 0.07 [0.03, 0.11]4 studies · 63 participantsLow
Rate of canine retraction
i-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 0–1 month
MD 0.26 [0.09, 0.44]4 studies · 94 participantsLow
Rate of canine retraction
L-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 1–2 weeks
MD 0.12 [0.09, 0.14]3 studies · 45 participantsLow
Rate of canine retraction
L-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 0–1 month
MD 0.54 [0.32, 0.76]5 studies · 77 participantsVery low
Rate of canine retraction
i-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 3–4 months
MD 0.17 [0.01, 0.34]4 studies · 94 participantsLow
Rate of canine retraction
i-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 1–2 months
MD 0.4 [0.18, 0.61]5 studies · 114 participantsVery low
Rate of canine retraction
L-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 3–4 months
MD -0.02 [-0.17, 0.13]2 studies · 27 participantsVery low
Rate of canine retraction
L-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 1–2 months
MD 0.33 [0.05, 0.62]7 studies · 108 participantsVery low
Rate of canine retraction
L-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 0–1 week
MD 0.04 [0.01, 0.07]3 studies · 45 participantsLow
Rate of canine retraction
i-PRF vs Conventional orthodontic treatment without APC, with or without placebo or sham · 2–3 months
MD 0.35 [0.1, 0.61]5 studies · 114 participantsVery low

1 including review in total.