Primary study · included by 1 review

Efficacy of analgesia promoted by lidocaine and articaine in third molar extraction surgery. A split-mouth, randomized, controlled trial.

de Souza Santos 2024 · de Souza Santos Samara, Bonatto Mariana Silva, Mendes Pedro Gomes Junqueira, et al. · Oral and maxillofacial surgery · 2024

Included by

Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials.
Non-Cochrane · intervention · 2026 · cited as de Souza Santos 2024 · Reference 35; Results (studies cited per outcome); Table 1
Outcome this study informsPooled effectEvidenceCertainty
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 105.44 [-10.44, 221.31]2 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 74.51 [18.75, 130.27]4 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.12 [-0.19, -0.05]3 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 36.0 [24.75, 47.25]5 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.24 [-0.39, -0.1]5 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.25 [-0.39, -0.11]8 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 38.79 [24.83, 52.75]5 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.97 [-1.77, -0.18]5 studiesGRADE not reported
Anesthetic onset time
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.27 [-0.40, -0.13]9 studies · 638 participantsModerate
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.35 [-0.57, -0.12]6 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 75.9 [33.57, 118.23]4 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 35.53 [17.3, 53.75]2 studiesGRADE not reported
Anesthetic duration
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 53.63 [29.64, 77.62]8 studies · 598 participantsHigh
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.21 [-0.43, 0.01]4 studiesGRADE not reported
Pain intensity (VAS)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 1.13 [-0.49, 2.75]4 studies · 318 participantsModerate
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 41.89 [29.73, 54.04]5 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.61 [-1.11, -0.1]5 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 58.84 [27.68, 89.99]7 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -1.15 [-2.24, -0.07]2 studiesGRADE not reported

1 including review in total.