evidencegaps
Primary study · included by 1 review

Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet-rich fibrin over platelet-rich fibrin alone in treatment of Grade II furcation defects: A randomized controlled double-blind clinical trial.

Dhande 2023 · Dhande Srushti K, Rathod Surekha R, Kolte Abhay P, et al. · Journal of periodontology · 2024

Included by

A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis.
Non-Cochrane · intervention · 2026 · cited as Dhande 2023 · Table 1; Included studies
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level (CAL) gain
Melatonin (ML) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 0.99 [0.76, 1.22]1 studyGRADE not reported
Clinical attachment level (CAL) gain
Melatonin (ML) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 0.99NRGRADE not reported
Bone fill (BF)
Melatonin (ML) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.45NRGRADE not reported
Bone fill (BF)
Melatonin (ML) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.07 [1.98, 2.15]1 studyGRADE not reported
Bone fill (BF)
Melatonin (ML) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 2.07NRGRADE not reported
Clinical attachment level (CAL) gain
Melatonin (ML) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)
SMD 0.99NRGRADE not reported

1 including review in total.