Primary study · included by 1 review

Effectiveness of zinc supplementation on the incidence of oral mucositis during chemotherapy and radiation: A meta‑analysis.

Liu X 2023 · Liu Xin, Zhang Weifang, Chen Yifan, et al. · Experimental and therapeutic medicine · 2023

Included by

The Efficacy and Safety of Nutritional Supplements for Cancer Supportive Care: An Umbrella Review and Hierarchical Evidence Synthesis.

Non-Cochrane · umbrella · 2026 · cited as Liu 2023 · Reference 60; Tables 2-8

Outcome this study informs	Pooled effect	Evidence	Certainty
Oral mucositis incidence (RTOG criteria) Zinc (oral capsules, mouthwash or rinse) vs Placebo	RR 0.77 [0.36, 1.64]	4 studies · 245 participants	GRADE not reported
Oral mucositis incidence (all scales) Zinc (oral capsules, mouthwash or rinse) vs Placebo	Subgroup analysis of OM incidence by cancer type: Head and neck cancer: NS (6 RCTs, n = 339)	6 studies · 339 participants	GRADE not reported
Oral mucositis incidence (all scales) Zinc (oral capsules, mouthwash or rinse) vs Placebo	RR 0.37 [0.20, 0.70]	2 studies · 212 participants	GRADE not reported
Oral mucositis incidence (WHO criteria) Zinc (oral capsules, mouthwash or rinse) vs Placebo	RR 0.49 [0.19, 1.26]	5 studies · 392 participants	Very low
Oral mucositis incidence (all scales) Zinc (oral capsules, mouthwash or rinse) vs Placebo	RR 0.67 [0.47, 0.95]	12 studies · 783 participants	Very low
Oral mucositis incidence (other scales) Zinc (oral capsules, mouthwash or rinse) vs Placebo	RR 0.77 [0.61, 0.97]	3 studies · 146 participants	GRADE not reported
Oral mucositis incidence (all scales) Zinc (oral capsules, mouthwash or rinse) vs Placebo	RR 0.31 [0.21, 0.45]	2 studies · 170 participants	GRADE not reported

1 including review in total.