evidencegaps
Primary study · included by 1 review

Tertiary lymphoid structures in head and neck squamous cell carcinoma improve prognosis by recruiting CD8+ T cells.

Wang M 2023 · Wang Mengyao, Zhai Rundong, Wang Mengqi, et al. · Molecular oncology · 2023

Included by

The Prognostic Significance of Tertiary Lymphoid Structures in Head and Neck Cancers: A Systematic Review and Meta-Analysis.
Non-Cochrane · prognostic · 2026 · cited as Wang M 2023 · Reference 27; Table 1; Fig. 2
Outcome this study informsPooled effectEvidenceCertainty
Overall survival
Absence of tertiary lymphoid structures (TLS-negative tumors) vs Presence of tertiary lymphoid structures (TLS-positive tumors, reference category) · Follow-up 24 to 120 months
HR 2.20 [1.74, 2.78]7 studies · 1465 participantsGRADE not reported
Disease-free survival
Absence of tertiary lymphoid structures (TLS-negative tumors) vs Presence of tertiary lymphoid structures (TLS-positive tumors, reference category) · Follow-up 24 to 120 months
HR 2.21 [1.49, 3.28]3 studies · 453 participantsGRADE not reported

1 including review in total.