evidencegaps
Primary study · included by 1 review

Tertiary lymphoid structures associate with improved survival in early oral tongue cancer.

Almangush 2022 · Almangush Alhadi, Bello Ibrahim O, Elseragy Amr, et al. · BMC cancer · 2022

Included by

The Prognostic Significance of Tertiary Lymphoid Structures in Head and Neck Cancers: A Systematic Review and Meta-Analysis.
Non-Cochrane · prognostic · 2026 · cited as Almangush 2022 · Reference 10; Table 1; Fig. 2
Outcome this study informsPooled effectEvidenceCertainty
Overall survival
Absence of tertiary lymphoid structures (TLS-negative tumors) vs Presence of tertiary lymphoid structures (TLS-positive tumors, reference category) · Follow-up 24 to 120 months
HR 2.20 [1.74, 2.78]7 studies · 1465 participantsGRADE not reported
Overall survival
Absence of tertiary lymphoid structures (TLS-negative tumors) vs Presence of tertiary lymphoid structures (TLS-positive tumors, reference category) · Follow-up 24 to 120 months
HR 1.97 [1.42, 2.73]3 studies · 575 participantsGRADE not reported

1 including review in total.