Primary study · included by 2 reviews

Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial.

Restrepo 2016 · Gohar Raneen Ahmed Abou El Gheit, Ibrahim Shereen Hafez, Safwat Omaima Mohamed · Clinical oral investigations · 2023

Included by

Efficacy of various interventions for the management of white spot lesions associated with fixed orthodontic treatment: a systematic review and network meta-analysis of randomized controlled trials.

Non-Cochrane · intervention · 2026 · cited as Restrepo 2016 · Table 1

The review does not say which of its outcomes this study informs.

Effect of Self-Assembling Peptide on White Spot Lesions in Orthodontic Patients: A Systematic Review and Meta-Analysis.

Non-Cochrane · intervention · 2026 · cited as Gohar 2023 · Table 1; Figure 3

Outcome this study informs	Pooled effect	Evidence	Certainty
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -2.18 [-3.92, -0.45]	5 studies	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.43 [-14.11, 11.25]	2 studies	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.68 [-2.71, -0.67]	8 studies · 395 participants	Very low
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.85 [-3.81, 0.11]	5 studies · 206 participants	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.63 [-3.65, 0.4]	3 studies · 158 participants	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.8 [-7.49, 3.89]	3 studies	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -2.13 [-4.61, 0.35]	2 studies	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.8 [-3.14, -0.47]	6 studies	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.75 [-2.99, -0.53]	7 studies	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.8 [-3.14, -0.47]	6 studies	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -1.43 [-14.11, 11.25]	2 studies	GRADE not reported
White spot lesion quantification (score, lesion size, fluorescence loss, microhardness, color change, mineral content) Self-assembling peptide P11-4 (alone or with fluoride or ACP) vs Fluoride varnish, ACP varnish or no treatment · 6 weeks to 6 months	SMD -0.68 [-2.21, 0.85]	2 studies	GRADE not reported

2 including reviews in total.