evidencegaps
Primary study · included by 1 review

Human periodontitis-associated salivary microbiome affects the immune response of diabetic mice.

He 2022 · He Jinzhi, Shen Xin, Fu Di, et al. · Journal of oral microbiology · 2022

Included by

Dysbiosis and Immune Crosstalk in Experimental Diabetic Periodontitis: A Systemic Review and Meta-Analysis of Preclinical Murine Studies.
Non-Cochrane · aetiology · 2026 · cited as He 2022 · Table 1; Reference list
Outcome this study informsPooled effectEvidenceCertainty
Immune activation and periodontal inflammation (combined)
Exposure to diabetic/dysbiotic oral microbiota or diabetic condition vs Normoglycemic/eubiotic controls (healthy microbiota, healthy-saliva microbiome, or probiotic-treated)
SMD (Hedges' g) 1.61 [1.13, 2.09]4 studiesGRADE not reported
Immune activation and periodontal inflammation (combined)
Exposure to diabetic/dysbiotic oral microbiota or diabetic condition vs Normoglycemic/eubiotic controls (healthy microbiota, healthy-saliva microbiome, or probiotic-treated)
SMD (Hedges' g) 3.73 [2.96, 4.51]4 studiesGRADE not reported

1 including review in total.