evidencegaps
Primary study · included by 1 review

Is perioperative antibiotic prophylaxis in the case of routine surgical removal of the third molar still justified? A randomized, double-blind, placebo-controlled clinical trial with a split-mouth design.

Kirnbauer 2022 · Kirnbauer Barbara, Jakse Norbert, Truschnegg Astrid, et al. · Clinical oral investigations · 2022

Included by

Perioperative Antimicrobial Prophylaxis for Invasive Dental Procedures: A Systematic Review and Random-Effects Meta-Analysis of Randomized and Placebo-Controlled Studies.
Non-Cochrane · intervention · 2026 · cited as Kirnbauer 2022 · Table 1; Figures 2-4
Outcome this study informsPooled effectEvidenceCertainty
Secondary continuous postoperative outcome (postoperative morbidity indicator, not further specified)
Perioperative antimicrobial/antibiotic prophylaxis (systemic antibiotics and/or local antiseptic) vs Placebo or no prophylaxis · Postoperative
MD 0.02 [-0.38, 0.42]5 studies · 596 participantsGRADE not reported
Primary pooled endpoint: procedure-related bacteremia or early infectious outcome (event proportion on a 0-1 scale entered as mean)
Perioperative antimicrobial/antibiotic prophylaxis (systemic antibiotics and/or local antiseptic) vs Placebo or no prophylaxis · Early perioperative
MD -0.17 [-0.45, 0.11]8 studies · 1407 participantsGRADE not reported
Primary pooled endpoint: procedure-related bacteremia or early infectious outcome (event proportion on a 0-1 scale entered as mean)
Perioperative antimicrobial/antibiotic prophylaxis (systemic antibiotics and/or local antiseptic) vs Placebo or no prophylaxis · Early perioperative
MD -0.12 [-0.31, 0.07]10 studies · 1950 participantsGRADE not reported

1 including review in total.