Primary study · included by 2 reviews
The impact of apical periodontitis, non-surgical root canal retreatment and periapical surgery on serum inflammatory biomarkers.
Bakhsh 2022 · Bakhsh Abdulaziz, Moyes David, Proctor Gordon, et al. · International endodontic journal · 2022
Included by
The review does not say which of its outcomes this study informs.
| Outcome this study informs | Pooled effect | Evidence | Certainty |
|---|---|---|---|
Serum interleukin-6 (IL-6) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 0.81 [-0.27, 1.90] | 3 studies | GRADE not reported |
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 2.86 [1.30, 4.43] | 4 studies | GRADE not reported |
Serum tumor necrosis factor-alpha (TNF-alpha) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 2.19 [0.61, 3.76] | 3 studies | GRADE not reported |
Serum ICAM-1 Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 32.15 [9.32, 54.99] | 2 studies | GRADE not reported |
Serum interleukin-6 (IL-6) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 1.55 [0.89, 2.21] | 1 study | GRADE not reported |
Serum interleukin-6 (IL-6) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 1.49 [0.82, 2.16] | 1 study | GRADE not reported |
Serum interleukin-6 (IL-6) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 0.45 [-1.07, 1.97] | 2 studies | GRADE not reported |
Serum VCAM-1 Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 0.00 [-0.01, 0.02] | 2 studies | GRADE not reported |
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 0.05 [-0.01, 0.10] | 7 studies | GRADE not reported |
Serum tumor necrosis factor-alpha (TNF-alpha) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 4.26 [3.02, 5.50] | 1 study | GRADE not reported |
Serum interleukin-6 (IL-6) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD -0.04 [-1.46, 1.39] | 2 studies | GRADE not reported |
Serum ICAM-1 Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 86.49 [63.54, 109.44] | 2 studies | GRADE not reported |
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 0.05 [0.01, 0.10] | 3 studies | GRADE not reported |
Serum tumor necrosis factor-alpha (TNF-alpha) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD -0.25 [-0.60, 0.10] | 2 studies | GRADE not reported |
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 0.24 [0.07, 0.40] | 7 studies | GRADE not reported |
Serum tumor necrosis factor-alpha (TNF-alpha) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 0.11 [-0.74, 0.97] | 2 studies | GRADE not reported |
Serum tumor necrosis factor-alpha (TNF-alpha) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 4.90 [3.60, 6.20] | 1 study | GRADE not reported |
Serum VCAM-1 Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 0.00 [-0.00, 0.01] | 2 studies | GRADE not reported |
Serum interleukin-6 (IL-6) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment) | MD 1.01 [0.10, 1.93] | 3 studies | GRADE not reported |
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 0.04 [0.03, 0.04] | 3 studies | GRADE not reported |
Serum tumor necrosis factor-alpha (TNF-alpha) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 1.04 [-0.38, 2.46] | 3 studies | GRADE not reported |
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months) | MD 1.24 [0.05, 2.44] | 4 studies | GRADE not reported |
2 including reviews in total.