Primary study · included by 1 review

The impact of fixed orthodontic appliances and clear aligners on the oral microbiome and the association with clinical parameters: A longitudinal comparative study.

Shokeen 2022 · Shokeen Bhumika, Viloria Edward, Duong Emily, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2022

PubMed 35248417 doi:10.1016/j.ajodo.2021.10.015Journal Article

Trial PICO

Not extracted yet. Trial-level population, intervention, comparator, outcomes and design will appear here after the trial extraction run. Until then, the reviews below describe the study.

Results

Not extracted yet. Per-trial results (events, means, effect and weight as each review's forest plot reports them) will appear here after the trial extraction run.

Included by

White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta- analysis.

Non-Cochrane · intervention · 2023 · cited as Shokeen 2022 · Table 4; Ref [16] (Am J Orthod Dentofacial Orthop 2022, prospective cohort); plaque meta-analysis (P1-O1, Figs 4/5/6) and microbiome

Outcome this study informs	Pooled effect	Evidence	Certainty
Plaque accumulation (Plaque Index) Clear aligners (CA) vs Conventional fixed orthodontic appliances (CF) · Range 1 to 18 months (maximum time-point per study)	SMD -1.79 [-3.63, 0.04]	3 studies · 111 participants	Moderate
Plaque accumulation (Plaque Index) Clear aligners (CA) vs Conventional fixed orthodontic appliances (CF) · 6 months	SMD -2.04 [-3.37, -0.70]	5 studies · 253 participants	Ungraded
Plaque accumulation (Plaque Index) Clear aligners (CA) vs Conventional fixed orthodontic appliances (CF) · Range 1 to 12 months (maximum time-point per study)	SMD -1.46 [-2.77, -0.15]	5 studies · 246 participants	Moderate
Plaque accumulation (Plaque Index) Clear aligners (CA) vs Conventional fixed orthodontic appliances (CF) · 3 months	SMD -1.08 [-1.93, -0.24]	5 studies · 211 participants	Ungraded
Plaque accumulation (Plaque Index) Clear aligners (CA) vs Conventional fixed orthodontic appliances (CF) · Maximum reported time-point per study (range 1-18 months)	SMD -1.58 [-2.57, -0.58]	8 studies · 357 participants	Ungraded
Plaque accumulation (Plaque Index) Clear aligners (CA) vs Conventional fixed orthodontic appliances (CF) · 12 months	SMD -2.14 [-3.64, -0.64]	3 studies · 113 participants	Ungraded

1 including review in total.