evidencegaps
Primary study · included by 1 review

The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial.

Rapone 2022 · Rapone Biagio, Ferrara Elisabetta, Santacroce Luigi, et al. · International journal of environmental research and public health · 2022

Included by

Oxygen-Based Adjunct Therapies in Periodontitis: A Systematic Review and Meta-Analysis Within the Framework of Hypoxia and Inflammation.
Non-Cochrane · intervention · 2025 · cited as Rapone 2022 · Table 1; reference 24; Figure 2
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level (CAL) change from baseline to follow-up
Adjunct ozone therapy (gaseous ozone, ozonated water, ozonated olive oil) to subgingival instrumentation vs Subgingival instrumentation alone · 1 to 3 months after initial treatment
SMD 0.53 [-0.14, 1.19]7 studies · 292 participantsGRADE not reported

1 including review in total.