Primary study · included by 1 review

Treatment time, pain experience and acceptability of the technique for caries removal in primary teeth using the ART approach with or without Brix3000™ papain gel: a preliminary randomised controlled clinical trial.

de Souza 2021 · de Souza T F, Martins M L, Tavares-Silva C M, et al. · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022

Included by

Comparative efficacy of chemomechanical caries removal and conventional mechanical caries removal for the treatment of primary molar caries in children: a meta-analysis.

Non-Cochrane · intervention · 2026 · cited as de Souza 2021 · Table 1; reference list; forest plots Figs. 3 to 9

Outcome this study informs	Pooled effect	Evidence	Certainty
Operative time Chemomechanical caries removal (CMCR), any agent vs Conventional mechanical caries removal (bur, curette or polymer bur)	SMD 1.89 [0.99, 2.79]	10 studies	GRADE not reported
Operative time Chemomechanical caries removal (CMCR), any agent vs Conventional mechanical caries removal (bur, curette or polymer bur)	SMD 2.75 [0.78, 4.73]	4 studies	GRADE not reported
Operative time Chemomechanical caries removal (CMCR), any agent vs Conventional mechanical caries removal (bur, curette or polymer bur)	SMD 2.1 [1.31, 2.89]	14 studies · 1209 participants	Moderate

1 including review in total.