Primary study · included by 1 review

Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.

Okada 2021 · Okada Ayako, Murata Takatoshi, Matin Khairul, et al. · PloS one · 2021

Included by

Periodontitis, Endothelial Dysfunction, and Systemic Inflammation: A Systematic Review and Meta-Analysis of Flow-Mediated Dilation.

Non-Cochrane · intervention · 2026 · cited as Okada 2021 · Table 1; Results 3.7

Outcome this study informs	Pooled effect	Evidence	Certainty
Endothelial function: brachial artery flow-mediated dilation (FMD, percentage points) Periodontal therapy (non-surgical, scaling and root planing, or intensive protocols) vs Control or standard care, less intensive therapy, or baseline (within-subject) · Short to intermediate follow-up (24 h to 12 months across studies)	MD 3.3 [1.7, 4.9]	6 studies · 340 participants	Moderate
Endothelial function: brachial artery flow-mediated dilation (FMD, percentage points) Periodontal therapy (non-surgical, scaling and root planing, or intensive protocols) vs Control or standard care, less intensive therapy, or baseline (within-subject) · Short to intermediate follow-up (24 h to 12 months across studies)	Sensitivity analyses restricted to randomized controlled trials showed a smaller and non-significant effect on FMD (numeric estimate not reported)	NR	GRADE not reported

1 including review in total.