Primary study · included by 1 review

Clinico-radiographic comparative evaluation of 1% metformin gel plus platelet-rich fibrin over platelet-rich fibrin alone in the treatment of Grade II furcation defects: A randomized controlled double-blind clinical trial.

Swami 2021 · Swami Renuka K, Kolte Abhay P, Kolte Rajashri A · Journal of periodontology · 2022

Included by

A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis.

Non-Cochrane · intervention · 2026 · cited as Swami 2021 · Table 1; Included studies

Outcome this study informs	Pooled effect	Evidence	Certainty
Bone fill (BF) Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 2.29	NR	GRADE not reported
Clinical attachment level (CAL) gain Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 1.91	NR	GRADE not reported
Clinical attachment level (CAL) gain Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 0.99	NR	GRADE not reported
Clinical attachment level (CAL) gain Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 1.91 [1.37, 2.46]	4 studies	GRADE not reported
Bone fill (BF) Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 2.29 [2.15, 2.44]	4 studies	GRADE not reported
Bone fill (BF) Metformin (MF) plus PRF vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 2.07	NR	GRADE not reported

1 including review in total.