evidencegaps
Primary study · included by 2 reviews

Systemic antibiotic therapy as an adjunct to non-surgical peri-implantitis treatment: A single-blind RCT.

De Waal 2021 · De Waal Yvonne C M, Vangsted Tine E, Van Winkelhoff Arie Jan · Journal of clinical periodontology · 2021

Included by

Impact and efficacy of systemic antibiotics for peri-implant diseases treatment: A systematic review and meta-analysis on clinical and microbiological outcomes.
Non-Cochrane · intervention · 2025 · cited as De Waal 2021 · Table 2; reference list

The review does not say which of its outcomes this study informs.

Risk-based efficacy of systemic and local antibiotics in nonsurgical treatment of peri-implantitis: A systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as De Waal 2021 · Table 1; reference 40
Outcome this study informsPooled effectEvidenceCertainty
Probing depth (PD) reduction
Systemic or local antibiotics adjunctive to nonsurgical debridement vs Nonsurgical mechanical debridement alone
SMD -0.666 [-1.014, -0.318]6 studies · 325 participantsGRADE not reported

2 including reviews in total.