Primary study · included by 2 reviews

Impact of root canal treatment on high-sensitivity C-reactive protein levels in systemically healthy adults with apical periodontitis - a preliminary prospective, longitudinal interventional study.

Poornima 2021 · Poornima L, Ravishankar P, Abbott P V, et al. · International endodontic journal · 2021

Included by

Impact of Endodontic Treatment of Teeth With Apical Periodontitis on Levels of Inflammatory Biomarkers Associated With Cardiovascular Risk: A Systematic Review and Meta-Analysis.

Non-Cochrane · intervention · 2026 · cited as Poornima 2021 · Table 1; References

The review does not say which of its outcomes this study informs.

Does endodontic treatment modify serum inflammatory markers of cardiovascular risk in individuals with asymptomatic apical periodontitis? a systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Poornima 2021 · Table 1; Figs. 2-4; reference list

Outcome this study informs	Pooled effect	Evidence	Certainty
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment)	MD 2.86 [1.30, 4.43]	4 studies	GRADE not reported
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months)	MD 0.05 [-0.01, 0.10]	7 studies	GRADE not reported
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment)	MD 0.05 [0.01, 0.10]	3 studies	GRADE not reported
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Baseline (before treatment)	MD 0.24 [0.07, 0.40]	7 studies	GRADE not reported
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months)	MD 0.04 [0.03, 0.04]	3 studies	GRADE not reported
Serum C-reactive protein (CRP) Endodontic treatment (non-surgical treatment or retreatment, with or without surgery) vs Internal control group (healthy individuals; own-control analysis) · Post-treatment (follow-up 7 days to 12 months)	MD 1.24 [0.05, 2.44]	4 studies	GRADE not reported

2 including reviews in total.