Primary study · included by 1 review

Anesthetic efficacy and safety of 2% lidocaine hydrochloride with 1:100,000 adrenaline and 4% articaine hydrochloride with 1:100,000 adrenaline as a single buccal injection in the extraction of maxillary premolars for orthodontic purposes.

Deshpande 2020 · Deshpande Nupoor, Jadhav Anendd, Bhola Nitin, et al. · Journal of dental anesthesia and pain medicine · 2020

Included by

Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials.

Non-Cochrane · intervention · 2026 · cited as Deshpande 2020 · Reference 14; Results (studies cited per outcome); Table 1

Outcome this study informs	Pooled effect	Evidence	Certainty
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.05 [0.9, 1.23]	3 studies	GRADE not reported
Anesthetic duration (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD 8.2 [-4.76, 21.16]	3 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -1.81 [-2.85, -0.78]	5 studies	GRADE not reported
Anesthetic duration (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD 27.34 [9.52, 45.16]	4 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.02 [0.94, 1.11]	9 studies	GRADE not reported
Anesthetic duration (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD 27.34 [9.52, 45.16]	4 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.05 [0.93, 1.18]	10 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.03 [0.98, 1.08]	12 studies · 989 participants	Moderate
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.07 [0.93, 1.23]	2 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.04 [0.95, 1.13]	5 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.01 [0.88, 1.16]	5 studies	GRADE not reported
Anesthetic duration 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD 18.68 [3.05, 34.30]	7 studies · 476 participants	Moderate
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.03 [0.93, 1.15]	6 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -0.57 [-0.99, -0.16]	2 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.04 [0.97, 1.12]	6 studies	GRADE not reported
Anesthetic onset time 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -1.34 [-2.21, -0.47]	7 studies · 705 participants	Low
Anesthetic duration (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD 10.02 [-3.71, 23.74]	2 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -2.2 [-3.36, -1.03]	3 studies	GRADE not reported
Anesthetic onset time (min) 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	MD -0.59 [-2.12, 0.95]	4 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.02 [0.98, 1.06]	10 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 0.99 [0.9, 1.09]	7 studies	GRADE not reported
Anesthetic success rate 4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia	RR 1.03 [0.96, 1.11]	9 studies	GRADE not reported

1 including review in total.