Primary study · included by 1 review

5-Fluorouracil Is Associated With a Decreased Recurrence Risk in Odontogenic Keratocyst Management: A Retrospective Cohort Study.

Caminiti 2021 · Caminiti Marco F, El-Rabbany Mohamed, Jeon Justin, et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2021

Included by

Exploring the use and efficacy of 5-fluorouracil in the management of odontogenic keratocysts: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2025 · cited as Caminiti 2021 · Tables 1 and 2; References
Outcome this study informsPooled effectEvidenceCertainty
Recurrence
5-FU (5% topical) after enucleation and peripheral ostectomy vs Modified Carnoy's solution (MCS) after enucleation and peripheral ostectomy · Follow-up 12 to 108 months across studies
RD -0.199 [-0.283, -0.114]5 studies · 181 participantsModerate
Postoperative paresthesia (any)
5-FU (5% topical) after enucleation and peripheral ostectomy vs Modified Carnoy's solution (MCS) after enucleation and peripheral ostectomy · Follow-up 12 to 108 months across studies
RD -0.158 [-0.281, -0.035]5 studies · 181 participantsModerate
Permanent paresthesia
5-FU (5% topical) after enucleation and peripheral ostectomy vs Modified Carnoy's solution (MCS) after enucleation and peripheral ostectomy · Follow-up 12 to 108 months across studies
RD -0.061 [-0.14, 0.018]5 studies · 181 participantsGRADE not reported

1 including review in total.