evidencegaps
Primary study · included by 1 review

Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikrein‑related peptidase 4 and tight junction proteins in ameloblasts.

Gao 2020 · Gao Jianghong, Li Xinmei, Gao Liping, et al. · International journal of molecular medicine · 2020

Included by

Effects of Antibiotics and Anti-Inflammatory Drugs on Enamel Development: A Systematic Review with Quantitative Synthesis.
Non-Cochrane · intervention · 2026 · cited as Gao 2020 · Table 2; reference list; Fig. 2/Fig. 3; Supplementary Table S2
Outcome this study informsPooled effectEvidenceCertainty
Enamel phosphorus content
Antibiotics (amoxicillin, amoxicillin plus clavulanate, erythromycin) and anti-inflammatory drugs (celecoxib, indomethacin, ibuprofen, acetaminophen) vs No medication (control) · Exposure during enamel development
SMD (Cohen's d) 0.46 [-0.31, 1.75]4 studiesGRADE not reported
Enamel calcium content
Antibiotics (amoxicillin, amoxicillin plus clavulanate, erythromycin) and anti-inflammatory drugs (celecoxib, indomethacin, ibuprofen, acetaminophen) vs No medication (control) · Exposure during enamel development
SMD (Cohen's d) 0.52 [-0.21, 1.46]4 studiesGRADE not reported

1 including review in total.