Primary study · included by 1 review
Redefining adequate margins in oral squamous cell carcinoma: outcomes from close and positive margins.
Jain 2020 · Jain Prateek V, Sharan Rajeev, Manikantan Kapila, et al. · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020
Included by
| Outcome this study informs | Pooled effect | Evidence | Certainty |
|---|---|---|---|
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.312 [1.693, 3.158] | 10 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.657 [0.622, 0.694] | 11 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.751 [2.062, 3.669] | 10 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.658 [0.623, 0.695] | 11 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.654 [0.619, 0.691] | 11 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.696 [0.626, 0.773] | 11 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.657 [0.622, 0.694] | 11 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.657 [0.622, 0.694] | 11 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.878 [2.123, 3.901] | 10 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.656 [0.620, 0.693] | 11 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.702 [2.026, 3.605] | 10 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.640 [0.605, 0.677] | 11 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.998 [2.209, 4.068] | 10 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.658 [0.623, 0.695] | 11 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.634 [0.545, 0.738] | 12 studies | Moderate |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.648 [1.970, 3.559] | 10 studies | GRADE not reported |
Overall survival (5-year) Positive surgical margins (mostly <5 mm; study definitions varied) vs Negative surgical margins (mostly 5 mm or more; one study 10 mm or more) | RR 0.656 [0.621, 0.693] | 12 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.958 [2.173, 4.026] | 10 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.647 [0.612, 0.685] | 11 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.700 [2.021, 3.608] | 10 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.724 [2.040, 3.636] | 10 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.719 [2.043, 3.619] | 11 studies | Moderate |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.658 [0.623, 0.695] | 11 studies | GRADE not reported |
Overall survival at 5 years Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · 5 years | RR 0.663 [0.628, 0.701] | 11 studies | GRADE not reported |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.718 [2.000, 3.695] | 10 studies | GRADE not reported |
Local recurrence Positive surgical margins (mostly <5 mm; study definitions varied) vs Negative surgical margins (mostly 5 mm or more; one study 10 mm or more) | OR 2.690 [1.921, 3.767] | 11 studies | Moderate |
Local recurrence Positive surgical margins (<5 mm) vs Negative surgical margins (>=5 mm) · Follow-up 1 to 5 years across studies | OR 2.565 [1.868, 3.522] | 10 studies | GRADE not reported |
1 including review in total.