evidencegaps
Primary study · included by 1 review

Anesthesia Onset Time and Injection Pain Between Buffered and Unbuffered Lidocaine Used as Local Anesthetic for Dental Care in Children.

Meincken 2019 · Meincken Melissa, Norman CaAdrian, Arevalo Oscar, et al. · Pediatric dentistry · 2019

Included by

Effectiveness of buffered local anesthetic solutions in pediatric nerve blocks and infiltration anesthesia: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Meincken 2019 · Table 1; Figs 2-4; reference list
Outcome this study informsPooled effectEvidenceCertainty
Onset time of anesthesia
Buffered local anesthetic (8.4% sodium bicarbonate added to lidocaine or articaine) vs Unbuffered (conventional) local anesthetic · During injection / procedure
SMD -1.55 [-3.67, 0.57]4 studies · 355 participantsGRADE not reported
Subjective pain perception during injection (WBFPRS, HP-VAS)
Buffered local anesthetic (8.4% sodium bicarbonate added to lidocaine or articaine) vs Unbuffered (conventional) local anesthetic · During injection / procedure
SMD -0.59 [-1.00, -0.17]3 studies · 295 participantsGRADE not reported

1 including review in total.