Primary study · included by 1 review

4% Articaine and 2% Lignocaine for Surgical Removal of Third Molar by Mandibular Nerve Block: A Randomized Clinical Trial for Efficacy and Safety.

Saralaya 2018 · Saralaya Shruthi, Adirajaiah Sahana B, Anehosur Venkatesh · Journal of maxillofacial and oral surgery · 2019

Included by

Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials.
Non-Cochrane · intervention · 2026 · cited as Saralaya 2018 · Reference 38; Results (studies cited per outcome); Table 1
Outcome this study informsPooled effectEvidenceCertainty
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 105.44 [-10.44, 221.31]2 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 74.51 [18.75, 130.27]4 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.12 [-0.19, -0.05]3 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 1.07 [0.88, 1.31]5 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 1.0 [0.69, 1.46]3 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 36.0 [24.75, 47.25]5 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 1.05 [0.91, 1.21]6 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.24 [-0.39, -0.1]5 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.25 [-0.39, -0.11]8 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 38.79 [24.83, 52.75]5 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.97 [-1.77, -0.18]5 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 1.09 [0.82, 1.43]5 studiesGRADE not reported
Anesthetic onset time
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.27 [-0.40, -0.13]9 studies · 638 participantsModerate
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.35 [-0.57, -0.12]6 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 75.9 [33.57, 118.23]4 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 1.37 [0.78, 2.41]3 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 35.53 [17.3, 53.75]2 studiesGRADE not reported
Anesthetic duration
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 53.63 [29.64, 77.62]8 studies · 598 participantsHigh
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 1.06 [0.90, 1.24]9 studies · 683 participantsLow
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.21 [-0.43, 0.01]4 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 41.89 [29.73, 54.04]5 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -0.61 [-1.11, -0.1]5 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 1.03 [0.88, 1.2]4 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 1.03 [0.78, 1.35]3 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD 58.84 [27.68, 89.99]7 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
MD -1.15 [-2.24, -0.07]2 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 0.95 [0.8, 1.14]4 studiesGRADE not reported
Anesthetic success rate
4% articaine with epinephrine, nerve block anesthesia vs 2% lidocaine with epinephrine, nerve block anesthesia
RR 0.85 [0.69, 1.04]3 studiesGRADE not reported

1 including review in total.