Primary study · included by 1 review

Clinico-radiographic evaluation of 1% alendronate gel as an adjunct and smart blood derivative platelet rich fibrin in grade II furcation defects.

Wanikar 2018 · Wanikar Ishita, Rathod Surekha, Kolte Abhay P · Journal of periodontology · 2019

Included by

A network meta-analysis of randomized controlled trials evaluating the evidence of pharmacological agents and growth factors in the regeneration of bony defects in chronic periodontitis.

Non-Cochrane · intervention · 2026 · cited as Wanikar 2018 · Table 1; Included studies

Outcome this study informs	Pooled effect	Evidence	Certainty
Bone fill (BF) Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 2.45	NR	GRADE not reported
Clinical attachment level (CAL) gain Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 1.89	NR	GRADE not reported
Bone fill (BF) Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 2.32	NR	GRADE not reported
Bone fill (BF) Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 2.45 [2.34, 2.56]	3 studies	GRADE not reported
Clinical attachment level (CAL) gain Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 1.89 [1.57, 2.21]	3 studies	GRADE not reported
Clinical attachment level (CAL) gain Alendronate (ALN) plus platelet-rich fibrin (PRF) vs PRF alone (placebo-containing PRF) · 6 and 9 months post-treatment (follow-up times combined)	SMD 0.99	NR	GRADE not reported

1 including review in total.