evidencegaps
Primary study · included by 2 reviews

Comparative evaluation of subgingivally delivered 1.2% rosuvastatin and 1% metformin gel in treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial.

Pankaj 2018 · Pankaj Dileep, Sahu Ipshita, Kurian Ida Grace, et al. · Journal of periodontology · 2018

Included by

Evidence on pharmacological agents for treating bony defects in chronic periodontitis: A network meta-analysis.
Non-Cochrane · intervention · 2025 · cited as Pankaj 2018 · Table 1; References

The review does not say which of its outcomes this study informs.

Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Pankaj 2018 · Figures 2-4; Tables 4-5 and reference list
Outcome this study informsPooled effectEvidenceCertainty
Probing pocket depth (PPD), change from baseline (mm)
SRP plus locally delivered 1.2% rosuvastatin gel vs SRP alone (placebo gel or no gel) · 6 months
MD 1.91 [1.35, 2.48]4 studies · 211 participantsGRADE not reported
Clinical attachment level (CAL), change from baseline (mm)
SRP plus locally delivered 1.2% rosuvastatin gel vs SRP alone (placebo gel or no gel) · 6 months
MD 1.94 [1.33, 2.56]4 studies · 211 participantsGRADE not reported

2 including reviews in total.