Primary study · included by 1 review

Patients with advanced periodontal disease before intensity-modulated radiation therapy are prone to develop bone healing problems: a 2-year prospective follow-up study.

Schuurhuis 2018 · Schuurhuis Jennifer M, Stokman Monique A, Witjes Max J H, et al. · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018

Included by

Periodontal Disease and Risk of Osteoradionecrosis in Patients with Head and Neck Cancer Undergoing Radiotherapy: A Systematic Review and Meta-Analysis.

Non-Cochrane · prognostic · 2026 · cited as Schuurhuis 2018 · ref 30; Table 1

Outcome this study informs	Pooled effect	Evidence	Certainty
Osteoradionecrosis of the jaws Periodontal disease or poor periodontal status (exposure) vs No periodontal disease, healthy or mild periodontal status	Pooled relative effect estimate (HR/OR/RR) 6.77 [2.65, 17.32]	5 studies	GRADE not reported
Osteoradionecrosis of the jaws Periodontal disease or poor periodontal status (exposure) vs No periodontal disease, healthy or mild periodontal status	Pooled relative effect estimate (HR/OR/RR) 4.83 [1.96, 11.93]	6 studies	GRADE not reported
Osteoradionecrosis of the jaws Periodontal disease or poor periodontal status (exposure) vs No periodontal disease, healthy or mild periodontal status	Pooled relative effect estimate (HR/OR/RR) 4.82 [1.50, 15.51]	6 studies	GRADE not reported
Prevalence of osteoradionecrosis of the jaws Radiotherapy for head and neck cancer	Pooled prevalence 0.09 [0.06, 0.13]	7 studies · 1785 participants	GRADE not reported
Osteoradionecrosis of the jaws Periodontal disease or poor periodontal status (exposure) vs No periodontal disease, healthy or mild periodontal status	Pooled relative effect estimate (HR/OR/RR) 4.55 [1.63, 12.69]	5 studies	GRADE not reported
Osteoradionecrosis of the jaws Periodontal disease or poor periodontal status (exposure) vs No periodontal disease, healthy or mild periodontal status	Pooled relative effect estimate (HR/OR/RR) 3.80 [1.45, 9.97]	5 studies	GRADE not reported
Osteoradionecrosis of the jaws Periodontal disease or poor periodontal status (exposure) vs No periodontal disease, healthy or mild periodontal status	Pooled relative effect estimate (HR/OR/RR) 3.94 [1.66, 9.35]	5 studies	GRADE not reported
Osteoradionecrosis of the jaws Periodontal disease or poor periodontal status (exposure) vs No periodontal disease, healthy or mild periodontal status	Pooled relative effect estimate (HR/OR/RR) 6.03 [2.32, 15.67]	5 studies	GRADE not reported
Osteoradionecrosis of the jaws Periodontal disease or poor periodontal status (exposure) vs No periodontal disease, healthy or mild periodontal status	Pooled relative effect estimate (HR/OR/RR) 4.81 [1.59, 14.55]	5 studies	GRADE not reported

1 including review in total.