Primary study · included by 1 review

Intracanal Cryotherapy Reduces Postoperative Pain in Teeth with Symptomatic Apical Periodontitis: A Randomized Multicenter Clinical Trial.

Vera 2018 · Vera Jorge, Ochoa Jorge, Romero Monica, et al. · Journal of endodontics · 2018

Included by

Cryotherapy as an adjunct in root canal therapy: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Vera 2018 · Table 1; Results text and Figs. 2-6

Outcome this study informs	Pooled effect	Evidence	Certainty
Incidence of postoperative pain Intracanal cryotherapy (cold irrigant, 1.5 to 4 C) vs Irrigation at room temperature	RR 0.72 [0.62, 0.84]	4 studies · 632 participants	High
Postoperative pain intensity (VAS/NRS) Intracanal cryotherapy (cold irrigant, 1.5 to 4 C) vs Irrigation at room temperature · 48 h	SMD -0.53 [-0.72, -0.34]	6 studies · 440 participants	High
Postoperative pain intensity (VAS/NRS) Intracanal cryotherapy (cold irrigant, 1.5 to 4 C) vs Irrigation at room temperature · 24 h	SMD -0.58 [-0.89, -0.27]	11 studies · 700 participants	High
Postoperative pain intensity (VAS/NRS) Intracanal cryotherapy (cold irrigant, 1.5 to 4 C) vs Irrigation at room temperature · 6 h	SMD -0.75 [-1.15, -0.35]	9 studies · 621 participants	High

1 including review in total.