evidencegaps
Primary study · included by 2 reviews

Comparative evaluation of subgingivally delivered 1% alendronate versus 1.2% atorvastatin gel in treatment of chronic periodontitis: a randomized placebo-controlled clinical trial.

Pradeep 2017 · Pradeep Avani R, Kanoriya Dharmendra, Singhal Sandeep, et al. · Journal of investigative and clinical dentistry · 2017

Included by

Evidence on pharmacological agents for treating bony defects in chronic periodontitis: A network meta-analysis.
Non-Cochrane · intervention · 2025 · cited as Pradeep 2017 · Table 1; References

The review does not say which of its outcomes this study informs.

Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Pradeep 2017 · Figures 2-4; Tables 4-5 and reference list
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level (CAL), change from baseline (mm)
SRP plus locally delivered 1.2% atorvastatin gel vs SRP alone (placebo gel or no gel) · 6 months
MD 1.70 [1.22, 2.19]6 studies · 332 participantsGRADE not reported
Probing pocket depth (PPD), change from baseline (mm)
SRP plus locally delivered 1.2% atorvastatin gel vs SRP alone (placebo gel or no gel) · 6 months
MD 1.39 [0.99, 1.79]6 studies · 332 participantsGRADE not reported

2 including reviews in total.