evidencegaps
Primary study · included by 1 review

Double-Blind Crossover Study to Compare Pain Experience During Inferior Alveolar Nerve Block Administration Using Buffered Two Percent Lidocaine in Children.

Chopra 2016 · Chopra Radhika, Jindal Garima, Sachdev Vinod, et al. · Pediatric dentistry · 2016

Included by

Effectiveness of buffered local anesthetic solutions in pediatric nerve blocks and infiltration anesthesia: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Chopra 2016 · Table 1; Figs 2-4; reference list
Outcome this study informsPooled effectEvidenceCertainty
Objective pain response (SEM, OSUBRS)
Buffered local anesthetic (8.4% sodium bicarbonate added to lidocaine or articaine) vs Unbuffered (conventional) local anesthetic · During injection / procedure
SMD -0.53 [-1.20, 0.15]3 studies · 226 participantsGRADE not reported
Onset time of anesthesia
Buffered local anesthetic (8.4% sodium bicarbonate added to lidocaine or articaine) vs Unbuffered (conventional) local anesthetic · During injection / procedure
SMD -1.55 [-3.67, 0.57]4 studies · 355 participantsGRADE not reported

1 including review in total.