evidencegaps
Primary study · included by 1 review

Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment.

Dolpady 2016 · Dolpady Jayashree, Sorini Chiara, Di Pietro Caterina, et al. · Journal of diabetes research · 2016

Included by

Dysbiosis and Immune Crosstalk in Experimental Diabetic Periodontitis: A Systemic Review and Meta-Analysis of Preclinical Murine Studies.
Non-Cochrane · aetiology · 2026 · cited as Dolpady 2016 · Table 1; Reference list
Outcome this study informsPooled effectEvidenceCertainty
Immune activation and periodontal inflammation (combined)
Exposure to diabetic/dysbiotic oral microbiota or diabetic condition vs Normoglycemic/eubiotic controls (healthy microbiota, healthy-saliva microbiome, or probiotic-treated)
SMD (Hedges' g) 1.61 [1.13, 2.09]4 studiesGRADE not reported
Immune activation and periodontal inflammation (combined)
Exposure to diabetic/dysbiotic oral microbiota or diabetic condition vs Normoglycemic/eubiotic controls (healthy microbiota, healthy-saliva microbiome, or probiotic-treated)
SMD (Hedges' g) 3.73 [2.96, 4.51]4 studiesGRADE not reported

1 including review in total.