evidencegaps
Primary study · included by 1 review

Rosuvastatin 1.2 mg In Situ Gel Combined With 1:1 Mixture of Autologous Platelet-Rich Fibrin and Porous Hydroxyapatite Bone Graft in Surgical Treatment of Mandibular Class II Furcation Defects: A Randomized Clinical Control Trial.

Pradeep Karvekar 2016 · Pradeep A R, Karvekar Shruti, Nagpal Kanika, et al. · Journal of periodontology · 2016

Included by

Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre-Implant Bone Regeneration: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Pradeep 2016 (furcation) · Figures 2-4; Tables 4-5 and reference list
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level (CAL), change from baseline (mm)
Open flap debridement with PRF (and HA in furcation) plus locally delivered statin gel (atorvastatin or rosuvastatin) vs Same surgical procedure without statin · 9 months
MD 0.69 [0.42, 0.96]3 studies · 190 participantsGRADE not reported
Probing pocket depth (PPD), change from baseline (mm)
Open flap debridement with PRF (and HA in furcation) plus locally delivered statin gel (atorvastatin or rosuvastatin) vs Same surgical procedure without statin · 9 months
MD 0.80 [0.56, 1.05]3 studies · 190 participantsGRADE not reported

1 including review in total.