Primary study · included by 1 review

Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: A trigger for BRONJ development?

Otto 2015 · Otto Sven, Tröltzsch Matthias, Jambrovic Vesna, et al. · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · 2015

Included by

Antibiotic Prophylaxis and Postoperative Therapy in Tooth Extractions for Patients at Risk of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Scoping Review.

Non-Cochrane · intervention · 2025 · cited as Otto 2015 · Table 1; reference 34; Figure 4

Outcome this study informs	Pooled effect	Evidence	Certainty
MRONJ incidence (MRONJ/bone exposure cases) High-dose bone-modifying agent therapy vs Low-dose bone-modifying agent therapy	OR 3.26 [1.74, 6.10]	16 studies · 1187 participants	GRADE not reported
MRONJ incidence (MRONJ/bone exposure cases) High-dose bone-modifying agent therapy vs Low-dose bone-modifying agent therapy	OR 33.5 [6.3, 177.8]	32 studies	GRADE not reported
MRONJ incidence (MRONJ/bone exposure cases) High-dose bone-modifying agent therapy vs Low-dose bone-modifying agent therapy	OR 2.82 [1.46, 5.43]	16 studies · 1187 participants	GRADE not reported

1 including review in total.