Primary study · included by 1 review

Efficacy of 4% articaine hydrochloride and 2% lignocaine hydrochloride in the extraction of maxillary premolars for orthodontic reasons.

Hassan 2011 · Hassan Shahid, Rao B H Sripathi, Sequeria Joyce, et al. · Annals of maxillofacial surgery · 2011

Included by

Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials.
Non-Cochrane · intervention · 2026 · cited as Hassan 2011 · Reference 15; Results (studies cited per outcome); Table 1
Outcome this study informsPooled effectEvidenceCertainty
Anesthetic duration (min)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD 8.2 [-4.76, 21.16]3 studiesGRADE not reported
Pain intensity (VAS)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -2.6 [-5.07, -0.12]4 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -1.81 [-2.85, -0.78]5 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD 27.34 [9.52, 45.16]4 studiesGRADE not reported
Pain intensity (VAS)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -3.16 [-6.09, -0.23]7 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD 27.34 [9.52, 45.16]4 studiesGRADE not reported
Pain intensity (VAS)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -2.38 [-3.43, -1.33]3 studiesGRADE not reported
Pain intensity (VAS)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -0.95 [-7.73, 5.84]3 studiesGRADE not reported
Anesthetic duration
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD 18.68 [3.05, 34.30]7 studies · 476 participantsModerate
Anesthetic onset time (min)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -0.57 [-0.99, -0.16]2 studiesGRADE not reported
Pain intensity (VAS)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -4.41 [-7.62, -1.21]7 studies · 418 participantsModerate
Pain intensity (VAS)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -5.2 [-8.01, -2.38]3 studiesGRADE not reported
Anesthetic onset time
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -1.34 [-2.21, -0.47]7 studies · 705 participantsLow
Pain intensity (VAS)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -8.72 [-16.04, -1.4]3 studiesGRADE not reported
Anesthetic duration (min)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD 10.02 [-3.71, 23.74]2 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -2.2 [-3.36, -1.03]3 studiesGRADE not reported
Anesthetic onset time (min)
4% articaine with epinephrine, infiltration anesthesia vs 2% lidocaine with epinephrine, infiltration anesthesia
MD -0.59 [-2.12, 0.95]4 studiesGRADE not reported

1 including review in total.